Failure Of Antibiotic Therapy

Failure Of Antibiotic Therapy

Principal : Antibiotic Therapy assessed to fail if fail to eliminate the symptom of clinic or recurrence infection again after therapy diihentikan.

Several things which can be used to trace the causes of fire failure :

* Ascertaining to return the infection cause ; whether or wrong diagnose; whether or what there is super infection

* Determining sensitivity of in vitro mikroorganisme for the antibiotic of used

* Do study of antibiotic rate in blood; urine; network and its activity to mikroorganisme.

* Ensuring that to chafe immanent just because infection is not because of other;dissimilar cause, for example hipersensitivitas to drug

* Factors of host for example patient compliance of posologi.

Inveterate mistake made at antibiotic therapy which can discomfit therapy.

This mistake basically centre around the antibiotic miscast, wrong of gift or antibiotic use, and or resistensi mikroorganisme.

Miscast antibiotic.

a. wrong antibiotic of target

b. Antibiotic given for the fever without documentation mikroorganisme

c. Using antibiotic which is not in vitro or unable to reach the den of infection of in vivo

d. Using toxic antibiotic although there is less toxic

e. Using costly antibiotic, although there is effective and cheap antibiotic.

Mistake of distributing antibiotic

- Wrong dose

- Distributing Route is not adequate

- Insufficient Use duration

- Fail to recognize the toxic occurence

- Dose modification do not at insuficiation elimination

- Changing antibiotic of certain factor matter at host needing correction

- Patient compliance of at posologi is not reached

Factor discomfiting antibiotic therapy.

Other;Dissimilar factor discomfiting antibiotic therapy such as :

a. Resistensi Mikroorganisme to used antibiotic

b. Happen by super infection

source :

Lecture Material Farmakodinami

By : Haryanto, SSi.Apt.