Therapy Antibiotic Failure

Therapy antibiotic failure

Principles:

Therapy antibiotics fail if the votes do not successfully remove the clinical symptoms of infection or relapse after therapy is stopped. Some things that can be used to explore causes failure therapy:

a. Make sure that the causes of re-infection, whether mistaken diagnosis, whether there superinfeks.

b. Determine the in vitro sensitivity to antibiotics of microorganisms used.

c. Undertake research kadar antibiotics in blood, urine, and network activity against microorganisms.

d. Make sure that the inflammation is still there only because the infection is not due for another, for example hiper sensitivity to drugs.

e. Factors in the host instance on patient compliance posologi.

Select the wrong antibiotic :
- Antibiotics are one of the target.
- Antibiotics are given for a fever without documentation microorganisms.
- Use of antibiotics in vitro is not able or do not reach breeding infection in vivo.
- Using antibiotics toksik even less toksik.
- Use antibiotics that expensive, although the available cheap and effectiv.

One provision or use:
- Dosage err.
- The route is not adequate.
- The timing of the use is not enough.
- Failed to recognize the incident toksik.
- Do not modify the dose insufisiensi elimenasi.
- Changing the antibiotics on the factors specific to the host that needs correction.
- The patient is not reached on posologi.

Factors that circumvent antibiotic therapy
Other factors that counteract antibiotic therapy is:
- Resistance of microorganisms to antibiotics used.
- There superinfeksi.

Source: "Lessons from my lecture"
Farmakodinami and antibiotics Terapi UGM